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41 Studies have found that individuals with lower CYP1A2 activity have increased reports of symptoms of toxicity, as caffeine is hepatically metabolized by CYP1A2 which causes caffeine to be absorbed more slowly

188 These genes are specifically expressed on the apical membrane of renal proximal tubule cells, which are crucial for the secretion of uric acid into the glomerular filtrate, as depicted in Fig

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