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[DOI] [PubMed] [Google Scholar] 135.Vaz FM, Scholte HR, Ruiter J, Hussaarts-Odijk LM, Pereira RR, Schweitzer S, de Klerk JB, Waterham HR, Wanders RJ

Cells have evolved a complex antioxidant system, formed by enzymatic antioxidants, such as superoxide dismutases (SODs), catalase (CAT) and glutathione peroxidases (GPXs), thioredoxin (Trx) as well as low molecular antioxidants, whose concerted action is balancing the level of oxidative stress (Halliwell 2022)

The suggested dithiol mechanism for the reduction of EcRNR by EcGrx1 comprises a dithiol-disulfide exchange reaction followed by the stepwise reduction of EcGrx1(S 2 ) and EcGrx1(SSG) by two molecules of GSH (Fig