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Reilley, M

Sirtuins as regulators of metabolism and healthspan

522,523,524 In vitro results demonstrated that mitochondria tend to form smaller and more fragmented ones in breast cancer cells treated with silibinin, indicating altered mitochondrial dynamics

"Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia"

However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10