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JTI - Japan Tobacco International is the international tobacco business of Japan Tobacco Inc., a leading international tobacco product manufacturer, with a global market share of almost 10%

Specifically, loss of dopaminergic neurons that project from the SN pars compacta to the caudate-putamen in the striatum leads to the impairment of dopamine neurotransmission, eliciting various clinical syndromes, including pathological motor features, such as a slowly progressive asymmetric resting tremor (bradykinesia), cogwheel rigidity, and gait disturbance, as well as non-motor features, such as anosmia, constipation, depression, sleep behavior disorder, autonomic dysfunction, pain, and psychiatric symptoms (Morris et al., 2024)

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An increase in NADPH oxidase activity was also observed by measuring serum levels of soluble NOX2-derived peptide after smoking only one tobacco cigarette [9]