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Itaconate, a mitochondria-derived immunometabolite, is significantly downregulated in patients with active SLE, and the loss of its antioxidant protection may contribute to disease activity [62]

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Four types of neutrophil granules have been identified, including specific granules, gelatinase granules, azurophilic, and secretory vesicles, with the azurophilic granules posing the greatest threat to phagocytic bacteria

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2015 Oct 2;10(10):e0139675