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Nevertheless, in cases of severe deficiency with neurological sequelae, we suggest that IM B12 is used in the first instance to replenish body stores with the treatment regimen, including dosage and formulation, optimised to keep the patient free of symptoms and tailored to the metabolic response of not only plasma B12 levels, but also confirmatory testing of homocysteine, methionine, and methylmalonic acid levels

Lower doses mean less medication drawn per injection, which means each vial lasts longer in terms of dose count, but the BUD does not change

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Development and Evaluation of a Three-Dimensional Multistation Cardiovascular Simulator

Chemistry 20, 88102