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Together these data demonstrate that treatment of melanoma cells with D-Nle-Cys-Ile-NH(CH 2 ) 5 CONH 2 radically prevented lung colonization and highlight the utility of the 6-AH analogs as anti-cancer agents

The phase III clinical trial in newly diagnosed GBM demonstrated a significant increase in overall survival by 4.9 months when combined with TMZ, in comparison to patients receiving TMZ alone (20.9 months and 16.0 months, respectively), resulting in the FDA approval of TTFields for GBM in 2015 (29)