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doi: 10.3389/frph.2022.822257 Received 25 November 2021 Accepted 17 January 2022 Published 22 February 2022 Volume 4 - 2022 Edited by Roland Eghoghosoa Akhigbe, Ladoke Akintola University of Technology, Nigeria Reviewed by Giulia Collodel, University of Siena, Italy

Based on the four dimensions of oral feasibility, gastric retention efficacy, difficulty in large-scale production, and regulatory acceptability, we can divide the existing nanomaterials into three progressive levels: Tier 1: pH-responsive monofunctional nanomaterials

This conversion process allows l-citrulline to maintain higher plasma l-arginine concentrations compared to direct l-arginine supplementation

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The mismatch not only wastes money but creates user friction, undermining confidence in the efficiency of NHS digital communications