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E.2003Study of the activity of glutathione-peroxidase, glutathione-transferase, and glutathione-reductase in renal transplants.3513461350

The canonical pathway is primarily triggered by MSU crystals through NLRP3 inflammasome activation and caspase-1 signaling, whereas the non-canonical pathway is mediated by caspase-4/5 in humans (caspase-11 in mice) in response to intracellular LPS

These microbial alterations may be closely linked to disease activity, treatment response, and pathological mechanisms in SLE, providing a promising foundation for future microbiota-based diagnostic and therapeutic strategies (Table 1)

Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione