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The interactions with the conserved Asn328 and several water molecules are also contributing to the stability of the C5 substrate

McArthur JC, McClernon DR, Cronin MF, Nance-Sproson TE, Saah AJ, St Clair M, Lanier ER

Levine, E

Ye Y, Zhou Y, Zhang L, Chen Y, Lyu X, Cai L, et al

Figure 7: Percentage aggregation of canonical (non-HLE) CD19xCD3 BiTE antibody construct as measured by SEC as a function of pH at TO, 7 days, 14 days and 1 month