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Individuals affected by pathogenic mutations in the deduced amino acid sequence of COQ4, COQ7, COQ9 , and/or PDSS1 develop encephalopathy and those affected by mutations in ADCK3/COQ8A develop mainly cerebellar disorders

[34] The greatest threat to life due to GHB overdose (with or without other substances) is respiratory arrest

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Sutcliffe S, Bavendam T, Cain C, Epperson CN, Fitzgerald CM, Gahagan S, Markland AD, Shoham DA, Smith AL, Townsend MK, Rudser K, Brubaker L, Mueller E, Hardacker C, Hebert-Beirne J, Lavender M, Burgio K, Lewis C, McGwin G, Williams B, Lukacz E, LaCoursiere D, Nodora J, Miller J, Chin-I An L, Low L, Harlow B, Brady S, Connett J, Chu H, Fok C, Lindberg S, Rockwood T, Newman D, Berry A, Schmitz K, Stapleton A, Wyman J, McNicholas C, James A, Lowder J, Rickey L, Camenga D , Chai T, Lewis J, Palmer M, Kirkali Z, Mullins C, Norton J

doi: 10.1016/j.bbrc.2007.09.107 4 AymerichM