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Consider avoiding things that increase (i.e., induce) CYP1b1 and CYP3a4 enzymatic activity Recall that CYP1b1 is the enzyme that converts estrogen to the 4-OH metabolites and CYP3a4 is the enzyme that converts estrone (E1) to the 16-OH-E1 metabolite, and estradiol (E2) to estriol (E3)

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And so does tendon

e , f , LX-2 cells were transfected with si APOL2 -1/2/3 ( e ) or APOL2 plasmid ( f ) for 6 h and subsequently treated with or without TGF-1 or different concentrations of DP for 48 h