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213,214,215 These genetic variants act as proxies for prolonged urate exposure, assuming they remain unconfounded by other factors

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In addition, altered thyroid hormones levels may cause changes in the number and activity of mitochondrial respiratory chain components which represent the principal cellular site of ROS production, ultimately leading to changes in the cellular redox environment and increased ROS generation (57, 58)

GHK-Cu: examined for collagen and matrix-related effects, and broader cellular responses in dermal and soft-tissue models

Puerarin 6-O-xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR