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Similarly, subcutaneous injection reduces tumor volume and inhibits angiogenesis in a breast cancer model, while intravenous injection inhibits tumor growth and angiogenesis and prolongs survival in hepatocellular carcinoma models

We also used affinity purificationmass spectrometry (APMS) to map the interactions of CRBN globally 42 , which revealed an exquisitely selective and dHTC1-dependent enrichment of ENL, AF9 and other members of the super elongation complex (SEC) (Extended Data Fig