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Age-related macular degeneration: genetic and environmental factors of disease

472 Therapeutic advances Since mitochondria affect disease progression in a variety of ways, emerging studies have been focusing on mitochondria-targeted therapies

Intracellular detection of ROS was achieved by incubating cells with 10 M CM-DCFDA for 30 min at 37C prior to LPS and GHK-Cu treatment

Wang Z, Wang Z, Lu T, Chen W, Yan W, Yuan K, Shi L, Liu X, Zhou X, Shi J, Vitiello MV, Han Y, Lu L

Although promising, gene therapy still faces key challenges, including vector immunogenicity, achieving precise tissue-specific expression regulation, safety assessment of long-term expression, and controllability of expression intensity (Jakabek et al., 2025)