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After completion of the reaction, the pH was adjusted to pH = 5-6 with hydrochloric acid solution (pH = 2)

Furthermore, it was demonstrated that exogenous pyruvate, functioning as a complementary substrate, impeded the reduction of fumarate under CB-839 treatment conditions

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In the ICD-10-CM system, the specific code for chronic macrocytic anemia is D63.8, falling under the category of Anemia in other chronic diseases classified elsewhere. This code is designed to encompass instances of macrocytic anemia associated with chronic conditions beyond those explicitly specified in other code categories