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GF mice have alterations in 5-HT1A serotonin receptor expression and NMDA receptor in the hippocampus, changes in myelination in the prefrontal cortex, and impairment of the blood-brain barrier (147150)

Eligibility & Dose Requirements Proof of your current prescription and dosage is required during your consultation. Your provider will verify your eligibility and determine the appropriate dose based on your treatment history. To qualify for 4.4mg/week, you must have been prescribed at least 2.2mg/week within the past 45 days. To qualify for 7mg/week, you must have been prescribed at least 4.4mg/week within the past 45 days. To qualify for 10mg/week, you must have been prescribed at least 7mg/week within the past 45 days. Patients requesting 13mg/week must have documentation of prior treatment at an appropriate dose, as determined by the prescribing provider

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Women should consult their healthcare provider about appropriate timing for discontinuation, as the medication has a half-life of approximately 5 days with elimination occurring over several weeks