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(download DOCX Heme degeneration catalyzed by HO-1

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Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37

Researchers have also explored DSIPs possible role in stress regulation, hormone signaling, and pain modulation, but the overall evidence remains preliminary and insufficient for definitive clinical recommendations

Furthermore, aloe-emodin exhibits anti-cancer activity against NSCLC (A549 and NCI-H1299) through Caspase-dependent apoptosis, autophagy induction via MAPK activation and AKT/mTOR inhibition, and ROS-mediated autophagy-triggered apoptosis, demonstrating its potential as a therapeutic candidate and synergize with gemcitabine [505]