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This notion is supported by previous data showing that in CD4 + T lymphocytes aerobic glycolysis was required for optimal IFN production, whereas in the absence of glucose the glycolytic enzyme glycerinaldehyde-3-phosphate-dehydrogenase (GAPDH) functioned as a repressor of IFN mRNA translation (Chang et al., 2013)

10.1016/j.freeradbiomed.2004.02.075 89 IydaJ

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Targeting the IGF-1R in breast cancer: clinical evidence Both in vitro and in vivo evidence strongly suggest that the IGF-1 system could serve as a promising target candidate in BrCa therapeutics

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