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Genetical disorders It has been clarified that the several genetic susceptibility to type 1 AIP as follows, the class II antigen haplotype of the major histocompatibility complex (HLA-DRB1*0405-DQB1*0401) [68] and, polymorphisms of Fc-receptor-like 3 genes [69] and cytotoxic-T lymphocyte antigen-4 gene (CTLA-4) [70, 71]

It targets dark patches, pigmentation, and dullness by penetrating deep into the skin layers

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