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The findings of DiGregorio et al challenge the classic presentation and argue for increased vigilance

Nat Rev Nephrol

USA 99 , 51335138 (2002)

The PIEZO2 mutation causing joint deformities reinforces the notion that abnormalities in proprioception may lead to musculoskeletal deformities [ 160 ]

Thus, the ENS is regarded as a second brain that can directly or indirectly respond to the microbiota and its metabolites influencing cognitive functions through gut bacteria (51)