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This is clinically relevant because obesity itself is associated with numerous health conditions that might influence treatment tolerance, including metabolic syndrome, cardiovascular disease, sleep apnea, and hepatic steatosis

Instead, it is focused more on fat-related pathways in the body

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When activated, beta-3-AR triggers Gs protein coupling, adenylyl cyclase activation, cAMP production, protein kinase A phosphorylation, and hormone-sensitive lipase translocation to lipid droplets for triglyceride hydrolysis