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bioRxiv2025 Jan 10

Endocrinology 2001

Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)

No study has tested these three together in animals or humans, so the synergy is reasoned from mechanism, not measured