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Mindfulness and Stress Management: Chronic stress exerts undue strain on the heart

While the phenotypic insulin resistance in NAFLD would be expected to counteract insulin-mediated SREBP1c activation, a state of selective insulin resistance ensures that insulin retains its ability to promote DNL through SREBP1c while being unable to suppress gluconeogenesis [41]

Additionally, miR-210 and miR-1246 have been identified as important markers for distinguishing AA patients from healthy controls [45]

S.Karger AG, 2013

However, sophisticated adaptive enzymatic mechanisms including superoxide dismutase (SOD), catalase and glutathione peroxidase (GPX), and nonenzymatic antioxidant defence systems such as glutathione (GSH) and vitamins (A, C, E) have evolved to metabolise ROS into less reactive forms to maintain physiological homeostasis and protect cells against oxidant stress [11, 16]