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According to the Henderson-Hasselbach equation, a drug that is a weak base will be mainly nonionized in alkaline urine and a weak acid will be mainly ionized in alkaline urine

Deboever N, Eisenberg MA, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC , Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Rajaram R

Body size analysis A developmentally synchronous population, derived from eggs laid over a 2-hour window, were cultured on NGA media at 25 C for 48 h, and then as young adult worms were transferred onto three treatment plates for an additional 24 h

Journal of Alzheimers disease: JAD 15 , 181191 (2008)

This ensures safe and effective treatment that accounts for side effects and individual responses