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These ketone bodies (KB), including acetoacetic acid (acetoacetate), acetone and beta-hydroxybutyric acid (HB), can be utilized by the brain, heart and skeletal muscle through the citric acid cycle (Krebs cycle) and act as an energy source when glucose is not readily available (see Figure 1) (57)

Moreover, up to now, few RNA therapies have been explored for cardiovascular diseases

Live Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice

[] Hepatic phosphatase and tensin homolog (PTEN)-mediated systemic metabolic homeostasis is related to the hepatokines

5-Oxoprolinase deficiency is associated with 5-oxoprolinuria but without a clear association with other symptoms