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In some research contexts, observations have included mild and transient tolerability-related effects such as: Headaches Nausea Stimulation-related observations Temporary injection-site irritation or localized skin-response variability Research conditions, concentration ranges, dosage ranges, hydration status, administration frequency, and protocol structure may influence tolerability observations across experimental settings

t = 1.29, p = 0.20) (see Supplementary Table 1), where the NAA peak-area SNR is defined as the ratio of the time-domain amplitude of the NAA CH 3 singlet divided by the standard deviation of the noise measured in the last 32 points of the time-domain signal