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Care 16, R178

insights from the ESC-EORP-HFA heart failure long-term registry

4-HNE is involved in PD pathology by covalently modifying -syn to promote its aggregation, disrupting the ubiquitin-proteasome system, and interfering with dopamine receptor function, and has been found to alter dopamine transport, contributing to dopamine loss (82, 86, 88)

In our CY 2023 PFS final rule, we issued an RFI to solicit public comment on strategies to update PE data collection and methodology (87 FR 69429 through 69432)