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Current studies have shown that 1) anomalous high SUA level is likely to induce a series of cardiovascular diseases, and acts as an independent risk factor for cardiovascular diseases, including atherosclerosis, hypertension, and coronary heart disease (Fernandes Silva et al., 2019

Most therapeutic compounds target a single pathway, but this peptide orchestrates a coordinated biological response through at least six distinct molecular routes

Nevertheless, the available evidence suggests that metformin holds promise as a potential therapeutic option for inflammatory diseases characterized by excessive accumulation of NETs due to neutrophil activation

Animal studies showed that DSIP pretreatment could protect against stress-induced ulcers, reduce stress-induced behavioral deficits, normalize stress hormone responses, and improve performance under stressful conditions

Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential