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Streeten, DHP

An elastase-induced rat IA model was established as previously described, with in vivo measurements of aneurysm incidence, rupture rates, and artery structural integrity

The C max values of each dose were 1.05 0.429, 3.30 0.508, and 26.1 7.82 ng/ml, respectively, and the AUC 0t values were 29.0 2.68, 160 21.0, and 830 247 ng min/mL respectively

Toxicol Lett 213(2):160166

Ketones are also critical for alleviating the toxicity of A, whereas -hydroxybutyrate reduces the toxicity of substance A42 in cultured hippocampal neurons and enables the cells to overcome amyloid-induced pyruvate dehydrogenase dysfunction [157]