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Psychiatry 170, 734741

By forming nonreactive molecules, Glutathione neutralizes hydrogen peroxide as well as oxygenated radicals that have disruptive effects on lipids, proteins, enzymes, and cellular DNA.

In addition to insulin resistance and hyperinsulinemia, NAFLD and CVD cluster with other common risk factors, including hypertension, hyperlipidemia, T2DM, obesity and inflammation (8)

Peroxisome proliferator-activated receptor (PPAR) synergizes with Nrf2 to enhance antioxidant gene expression and suppress ferroptosis

Furthermore, increased functional urease activity (urease B) and the production of ammonia disrupt the cellular cytoskeleton-mediated tight junctions by regulating the phosphorylation of myosin light chain (MLC) and endocytosis of the tight junction protein occluding, leading to enlarged intercellular spaces (Wroblewski et al., 2009)