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Many drugs look promising in cells, mice, or tissue samples but fail in later stages because: The treatment doesnt work well enough in humans It causes side effects at real doses The effect fades over time The human joint environment is much more complex than the lab So while we are hopeful, there is a long road ahead before this approach could become a real treatment

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GLP-1 and GIP receptor agonists have a low intrinsic risk of causing hypoglycaemia when used alone, because their insulin-stimulating effects are glucose-dependent