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WES identified a novel frameshift mutation in exon 2 of NF1 , c.165_166insCT (p.I55fsX), which was located in a highly conserved region (Supplementary Fig

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Cells were cultured and maintained DMEM/Ham's F-12 (Merck KGaA) supplemented with 10% FBS (Thermo Fisher Scientific, Inc.) and 100 g/ml streptomycin/100 units/ml penicillin (Thermo Fisher Scientific, Inc.) at 37C in a humidified atmosphere containing 5% CO2