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The composition according to any of claims 1 -1 148, wherein the one or more biological active molecules and the one or more multimerization domain are coupled by a mechanism comprising biotinylation

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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]