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In a mouse model, these liposomes exhibited superior penetration capabilities and led to a significant reduction in cutaneous eosinophil count, erythema, and irritation compared to commercially available ointments and creams [113, 114]

in colon tissue, assessing NO levels and oxidative stress (MDA levels) (as result of the lysis of endothelial cells) and ischemia/reperfusion injury, both as a spontaneous course [when blood supply was deprived via ligation (IC rats)] and a more exaggerated course [after ligation removal (IC + RL rats)] in immediate post-ligation time

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Further, it inhibited GSDME-mediated pyroptosis of hepatocytes and macrophages by both caspase-3 and GzmB pathways