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Moreover, a phase 1 clinical investigation of vutrisiran (NCT02797847) 217 showed that the reductions in serum TTR were well maintained for as long as 1 year after a single dose of vutrisiran for all six dose groups from 5 to 300 mg

First, we screened a collection of 23 ebselen and 11 ebselen diselenide derivatives and determined the half-maximum inhibitory concentration (IC 50 ) values for the most promising 2-phenylbenzisoselenazol-3(2 H )-ones to evaluate their properties as SARS-CoV-2 PL pro and M pro inhibitors