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Combined intestinal loss of PPAR// attenuates KD-driven intestinal stem cell expansion, proliferation and clonogenicity, whereas inhibition of downstream fatty acid oxidation through CPT1A loss limits adenoma formation specifically under KD, linking tumour initiation to fatty acid oxidation of dietary lipids rather than lipid accumulation

10.1146/annurev-biochem-011520-105053 16

k , QPCR analysis of PRKAA1 and PRKAA2 mRNA levels in shCtrl and shAMPK1 Huh7 cells

ATF4 integrates stress and metabolic signals through heterodimerization with members of the C/EBP family or with nuclear factor erythroid 2-related factor 2 (NRF2) to coordinate adaptive transcriptional programs (80-82)

They may shrink over time, causing loss of space between the vertebrae