PMID: 38139825
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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted
DOCTOR SUPERVISED GLP-1 PRESCRIPTION *Semaglutide (Ozempic and Wegovy generic) with added B12 vitamin
Furthermore, DSIP influences the hypothalamic-pituitary-adrenal (HPA) axis, regulating the bodys response to psychological and physical stress and significantly lowering cortisol (the primary stress hormone)