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doi: 10.1186/s12974-018-1381-4 174 VanElzakkerMBBrumfieldSALara MejiaPS

Test-Learn The predicted condition was demonstrated experimentally using the exact initial concentration of substrate and incubation time as found in the in silico model

Discoveries beginning in the early 2000s revealed that AMPK and mTORC1 communicate, or cross-talk, through direct and indirect phosphorylation events to regulate the activities of each other and their shared protein substrate ULK1, the master initiator of autophagy, thereby allowing cellular metabolism to rapidly adapt to energy and nutritional state

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