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Study designs often lack the rigor expected by Western regulatory standards

Similar content being viewed by others Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that manifests with inflammation and ulcers in the colonic lining, resulting in a spectrum of symptoms including abdominal pain, diarrhea, rectal bleeding, tenesmus (a sense of pressure), and weight loss [1, 2]

10.1039/d1nr06342a 123 SelmiM.SalekA.BarbouraM.NjimL.TrabelsiA.LahmarA.et al (2023)

JAMA 2023;329:21423

ICA, a metabolite with dual originsderived both from gut microbial Trp catabolism and the breakdown of compounds in cruciferous vegetables (112, 160163)exemplifies ligand-specific modulation of the AhR and competitive interplay within critical immunometabolic pathways