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Endothelial-to-mesenchymal transition (EndMT) is driven by similar signaling mechanisms as EMT (Snail-1, Slug (Snail-2) and Twist-1/2) and leads to the loss of characteristic endothelial markers PECAM-1/CD-31, VE-cadherin, vascular endothelial growth factor receptor 2 (VEGFR2) and endothelial nitric oxide synthase (eNOS)

However, ( S )-dHTC1 showed a dramatic improvement in the CRBN FP assay when ENL YEATS was added to the assays, whereas ( R )-dHTC1 remained largely inactive (Extended Data Fig

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There is, of course, no possibility to make revenue during the development phase