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However, several challenges remain, including low bioavailability, an incomplete understanding of their mechanisms, uncertainties about the optimal dosing regimen, and the potential interactions among different polyphenols

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These results are consistent with the previous in vivo experiments using dextran with different molecular weights (3 to 2000 kDa), in which the opened BBB gaps ranged from 2.3 to 54.4 nm depending on the acoustic pressure 42,43