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SARS-CoV-2 specific CD8 + T cells in the nasal mucosa were found to persist 2 months after viral clearance, indicating the long-term effects of COVID-19 on immune reactions in the upper respiratory tract (Roukens et al., 2022)

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Chronic inflammation is sustained by the constitutive activation of key signaling pathways such as NF-B, JAK/STAT, p38 MAPK, COX-2, ERK, mTOR, and AP-1, which drive transcription of genes involved in inflammation, survival, and proliferation [39]