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Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia

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Glutathione (GSH) profile INCI: Glutathione CAS number: 70-18-8 Description: white solid Melting point: 185 to 195 degrees Celsius Solubility: in water and dimethylformamide Effect: extremely effective as a radical scavenger, detoxifies, stimulates natural repair processes Areas of application: perfect as an innovative anti-ageing booster We like to work with these glutathione-containing active ingredients: Glutathione (GSH) for sophisticated formulations from Cosmacon Glutathione (GSH) can actually be described in just one sentence: The tripeptide is the mother of all antioxidants

Abbreviations ASL: Airway surface liquid ALI: Airliquid interface COPD: Chronic obstructive pulmonary disease WHO: World health Organization PM: Particulate Matter AED: Aerodynamic equivalent diameter ROS: Reactive oxygen species RNS: Reactive nitrogen species NAC: N-acetylcysteine hNEC: Human nasal epithelial cell poly I:C: Polyinosinic:polycytidylic acid HDM: House dust mite BaP: Benzo[a]pyrene CYP27B1: 1-Hydroxylase RSV: Respiratory syncytial virus hBEC: Human bronchial epithelial cell LPS: Lipopolysaccharide BALF: Bronchoalveolar lavage fluid TH17: T helper 17 DEP: Diesel exhaust particle EMT: Epithelial-mesenchymal transition CSE: Cigarette smoke extract GSH/GSSG: Glutathione (reduced/oxidized) CF: Cystic fibrosis IPF: Idiopathic pulmonary fibrosis References Yang W

However, preclinical models always constitute approximations and simplifications, and therefore, results should be interpreted with caution (180)