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The global market value for bleaching treatments is projected to jump from an estimated $10 billion in 2021 to $16 billion in 2030, Dozens of Facebook pages in Cameroon, Ivory Coast, Niger and Senegal promise uniform whitening thanks to various creams or injections

To address these limitations, innovative approaches such as gold nanoparticle-assisted low-speed centrifugation have been developed, enabling efficient isolation of small EVs with significantly reduced processing time and equipment requirements [84] [Table 1]

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Finally, by increasing the affinity of lipoprotein (a) for fibrin, homocysteine would inhibit the conversion of plasminogen into plasmin on the fibrin surface (Harpel et al, 1992