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Hepatology 42 , 362371 (2005)

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Collectively, these late effects illustrate the narrow therapeutic window inherent to brachytherapy: the difference between a curative dose and the threshold for debilitating toxicity is small, particularly in patients with complex pelvic anatomy or advanced disease

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The PTL AC was further modified to PTL ACair by adding air bubbling into the plasma system to render better antimicrobial efficacy