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There are also microbial contamination concerns with refillable vessels over time

(PubMed) Cheng TY, Barnett MJ, Kristal AR, et al

We will present this in detail in the next section

Several studies have also suggested that excess FA causes inhibition of folate-dependent pathways, promoting the thymidylate synthase (TS) process rather than the methionine synthase (MTR) cycle