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This concentration balances solubility with practical application volumes higher concentrations (above 5mg/mL) risk incomplete dissolution and peptide aggregation, while lower concentrations require larger application volumes that dilute the effective dose per surface area

and is activated upon either carbon or nitrogen starvation during vegetative growth.300 On the other hand, the mpkA regulates cell wall integrity signaling and pyomelanin formation,284 and mpkC regulates conidial germination in response to the carbon source in the medium.233 The mpkA deletion has been carried out but no influence was observed on virulence of the mutant strain in a murine infection model,283 while the other genes have not been yet tested for virulence

"Glutathione and mitochondria." Frontiers in Pharmacology, 2014