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The synergy might arise from the combined action of GHK-Cu in stimulating glycosaminoglycan production, promoting collagen synthesis, and HA's role in reducing collagen degradation by scavenging reactive oxygen species and inhibiting matrix metalloproteinases

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When administered via intra-articular injection to patients with knee osteoarthritis, the 5-year efficacy and safety results showed that sprifermin effectively modified cartilage, leading to reductions in patient pain and the rate of knee replacement surgeries [431]

Pulmonary neuroendocrine cells function as airway sensors to control lung immune response