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KRAS mutations are frequently associated with upregulated COX-2 expression and increased PGE2 production, thereby stimulating tumor cell proliferation and reinforcing immune evasion within the TME

Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM

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Studies have indicated that these two phototherapeutic approaches not only directly eliminate tumors but also enhance regulating cell death mechanisms including ferroptosis and cuproptosis